Inhibition of Matrix Metalloproteinase and Hypertension
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinase inhibition mitigates renovascular remodeling in salt-sensitive hypertension
Extracellular matrix (ECM) remodeling is the hallmark of hypertensive nephropathy. Uncontrolled proteolytic activity due to an imbalance between matrix metalloproteinases and tissue inhibitors of metalloproteinases (MMPs/TIMPs) has been implicated in renovascular fibrosis. We hypothesized that inhibition of MMPs will reduce excess ECM deposition and modulate autophagy to attenuate hypertension....
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 2007
ISSN: 0916-9636,1348-4214
DOI: 10.1291/hypres.30.477